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This dual-action mechanism may make tirzepatide more effective for weight loss than other similar medications

It will complete a phase III clinical trial in 2021 to manage type 2 diabetes mellitus (T2DM) (Urva et al

Beyond alcohol use disorder, the medications also reduced the risk of hospitalization for any substance use disorder and physical illnesses

As for ketogenic diet, a study in eight hospitalized patients with PWS (age 918 years) showed that a low-carbohydrate high-fat diet (15% carbohydrate, 65% fat, and 20% protein) increases glucagon-like peptide-1 (GLP-1) and reduces ghrelin/GLP-1 ratio, possibly limiting food intake and improving glycemic control as compared to a low-fat high-carbohydrate diet (65% carbohydrate, 15% fat, and 20% protein) [86]